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GLP-1 medications are not a permanent solution on their own - research on weight regain after discontinuation is ongoing, and many patients experience some weight regain after stopping therapy

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Mustapha JA, Katzen BT, Neville RF et al (2018) Determinants of long-term outcomes and costs in the management of critical limb ischemia: a population-based cohort study

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SURMOUNT-1 trial (NCT04184622, estimated study completion in May 2024) is testing the ability of tirzepatide (at doses of 5, 10, or 15 mg) to reduce weight in subjects with diabetes and obesity at 72 weeks