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In fact, treatment with an Si-based agent suppresses both the development of renal failure and the decrease in motor coordination in Parkinson's disease 12
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Bondue T, Berlingerio SP, Siegerist F, Sendino-Garvi E, Schindler M, Baelde HJ, Cairoli S, Goffredo BM, Arcolino FO, Dieker J, Janssen MJ, Endlich N, Brock R, Gijsbers R, van den Heuvel L, Levtchenko E (2023) Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis