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Lutz and coworkers could establish that the antigenic site preexists in band 3 protein, but becomes accessible for NAb binding upon band 3 clusterization e.g., on spectrin-free vesicles in which band 3 is laterally mobile

doi:10.1016/j.cell.2007.03.024

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ALS: bulk of the iceberg Human neuroimaging and post-mortem studies show that impaired mitochondrial biology occurs early in the pathogenesis of ALS [54]