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Here's the mechanism: the enzyme ALDH2 (aldehyde dehydrogenase 2) oxidises acetaldehyde into acetic acid, but this process requires adequate glutathione reserves to neutralise reactive oxygen species (ROS) generated during the reaction

Kim JS, Jegal KH, Park HR, Choi BR, Kim JK, Ku SK

Treatment involves addressing the cause and sometimes vitamin B12 supplements or injections

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Comparison of whole-blood glutathione peroxidase activity, levels of serum selenium, and lipid peroxidation in subjects from the Fishing and Rural Communities of Rabo de Peixe village, San Miguel Island, the Azores Archipelago, Portugal