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Further research is needed to improve our understanding of their effects on obesity-related comorbidities and the underlying mechanism, whether involving direct effects on target tissues or mediated by improvement in BW, glucose levels and other CV risk factors

Berberine also restored protein phosphate 2A (PP2A) activity and glycogen synthase kinase 3 (GSK-3) activity (GSK-3 Tyr216 and Ser9 site phosphorylation increased) (Yu et al., 2011)

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