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If people stop medication, many are likely to need ongoing nutritional and behavioural support, and health services should anticipate that cardiometabolic benefits may lessen as weight is regained, Spreckley said, adding that this highlights the need for further research into effective, scalable strategies for long-term weight maintenance alongside pharmacotherapy. GLP-1 medications have become widely used in recent years, and more than 15 million Americans are now losing weight with the drugs

Healthcare professionals often recommend semaglutide to individuals with a body mass index (BMI) indicating obesity or as part of a comprehensive weight loss journey

Injecting within 48 hours of your previous dose significantly increases the risk of gastrointestinal adverse events and provides no therapeutic benefit

Cardiovascular side effects Most common events

Because metabolism influences immune cell behaviour, researchers are exploring whether metabolic signals may shape the disease environment