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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

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At the transcriptional level, mRNA expression of these markers increased 1.61.8-fold in treated cells relative to controls

Using firm pressure, clean the skin at the injection site

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