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Mechanistic validation revealed that the use of the mTOR activator MHY1485 reversed the anti-inflammatory effects of hydrogen, thereby confirming its regulation of microglial transformation via the mTOR-autophagy axis and providing molecular evidence for hydrogen therapy in sepsis-associated encephalopathy (SAE) (Zhuang et al., 2020)

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Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial