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Studies have reported that the use of bisphosphonates can delay bone metastasis in patients with breast cancer and improve overall survival (36,37)
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Their findings indicated that transcriptional repression of various drug-metabolising enzymes and transporters was induced through the modulation of farnesoid X receptor (FXR), liver X receptor (LXR), peroxisome proliferator-activated receptor (PPAR), pregnane X receptor (PXR), and vitamin D receptor (VDR) (100)
10.6092/ISSN.2531-7342/10712 Mekuria A, Xia L, Ahmed TA, Bishaw S, Teklemariam Z, Nedi T, Abula T, Engidawork E, Gong YY (2023) Contribution of aflatoxin B1 exposure to liver cirrhosis in eastern ethiopia: a case-control study