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these findings indicate that the ActRIIA/B receptor system in muscle responding specifically to these two ligands is largely responsible for the muscle loss associated with caloric restriction

GLP-1 use is safe and effective with many pre-existing conditions with the exception of the following: Currently pregnant Currently breastfeeding Currently being treated for cancer Active eating disorder Active gallbladder disease Active substance abuse or dependency Type 1 diabetes Bariatric surgery (within the past 18 months) Pancreatitis within the past 6 months, or a history of pancreatiitis caused by taking a GLP-1 Personal or family history of medullary thyroid cancer or MEN syndrome Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Expect prior-auth friction, but NEJM-level separation strengthens the case for patients aiming for higher loss thresholds or struggling to reach 10% on current therapy

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However, visible weight loss happens after several weeks