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* **Fatigue:** Feeling tired or weak

This ability of melatonin to regulate the above signaling cascades reinforces its anti-proliferative effects and pro-apoptotic properties [9, 103]

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Recent strategies to improve immunocompatibility include the incorporation of biomimetic coatings, the use of stealth polymers such as PEG and zwitterionic layers, and the design of surface modifications that minimize opsonization

It is made from three specific amino acids: cysteine, glutamate, and glycine

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