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In addition, an overexpression of soluble Klotho (sKlotho) protein which inhibits the function of IGF-1 receptor (IGF-1R) (Fig

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Therefore, aberrant regulation of this network can result in either loss of a specific germ cell type or over-proliferation of undifferentiated germ cells, which is associated with germline tumors (Wong et al., 2005)

Melanin is not commonly observed in routine biopsies of the oral mucosa, unless the tissues were obtained from nonCaucasoid individuals