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As NAD+ levels decline with age, obesity, and metabolic disease, sirtuin function diminishes, contributing to insulin resistance, mitochondrial dysfunction, and fat accumulation

Used in tissue repair and healing research, musculoskeletal injury models, GI mucosal biology, nitric oxide pathway studies, and combination peptide pharmacology

Hong JY, Lee CY, Lee MG, Kim YS

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A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation

Chao, C