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Spironolactone Sleep Impact and Optimization At a glance Drug class / aldosterone antagonist and potassium-sparing diuretic Common sleep-related complaint / nocturia (nighttime urination) reported in 10 to 30% of users Primary mechanism of sleep disruption / diuresis peaking 3 to 6 hours post-dose Dose range for acne and hirsutism / 50 to 200 mg per day (oral) Best dosing window to protect sleep / morning, ideally before 10 a.m

The principal serious adverse reactions are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain and/or pleural effusion, (2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births and (4) Arterial thromboembolism

A forward chemical genetic screen reveals an inhibitor of the Mre11Rad50Nbs1 complex

(2019) 316:C13553

in Modern Nutrition in Health and Diseases (ed