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In spontaneously hypertensive rats, carbidopa, which decreases peripheral dopamine by inhibiting peripheral dopamine synthesis, significantly accelerated the development of hypertension, decreased urinary sodium excretion, and decreased urinary and renal dopamine levels (Yoshimura et al., 1987)

IV drips higher dosage , makes 2 shade light in first month because of higher dosage administration while IM injections make one shade light in first month

Sarkar et al

(trusted non-journal) Cleveland Clinic

References [1] Saravanan P, Siddique H, Simmons D, Greenwood R, Dayan C

Results build over time as the skin undergoes gradual repair and regeneration