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To Raufman's surprise, in 1981 he discovered that when he put one of the peptides onto guinea pig pancreata, it caused a sharp rise in amylase, an enzyme made in the pancreas and salivary glands in the mouth to help the body break down carbohydrates (Raufman, Tensen, Sutliff

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In a separate trial of 62 patients with moderate-severity PD, exenatide had positive and sustained effects on motor function after 12 weeks

The dosage can be adjusted up to a maximum of 15 mg per week, depending on how well the patient responds to the treatment and any side effects they may experience

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