Obesity is a multifaceted disease that contributes directly and indirectly to atherosclerotic CVD, heart failure, atrial fibrillation and multiple CVD risk factors, including dyslipidaemia, type 2 diabetes, hypertension and sleep disorders (Figure)
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Thus, randomized controlled trials are needed to determine the true efficacy of gastric bypass reversal or gastric pouch versus subtotal or total pancreatic resection
Lancet 2009;373:1849-60.ArticlePubMedPMC 685
However, the exact role of gut dysbiosis in the pathogenesis is still a matter of debate, and it cannot be said whether these alterations precede, cause, or are a consequence of immunologic or metabolic changes that accompany ME/CFS [23]
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