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However, researchers note these are in vitro measurements that do not directly translate to in vivo outcomes

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There is also some evidence, such as asymmetric cross-tolerance (Pasternak, 2001) and tolerance-rescue studies (He et al., 2002), to suggest that mechanisms of tolerance may differ for different types of agonist

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Within weeks, Amanda reported a significant improvement in her energy levels and mental clarity

However, researchers also noted that the overall clinical effect appeared limited and difficult to reproduce consistently across larger populations