r/retatrutide Retatrutide — Research Peptide Signal transduction in HAP. Putative

Assuming Eli Lilly follows a similar timeline to tirzepatide, the earliest possible FDA approval for retatrutide would likely occur in late 2027 or 2028, depending on Phase 3 trial results and regulatory review timelines

Benefits include: reduced appetite slower gastric emptying improved satiety after meals decreased cravings for sugary and high-fat foods lower blood sugar spikes The GLP-1 effect is fundamental to nearly every modern metabolic drug, but retatrutide does not stop at this single pathway

J Med Chem (2000) 43(9):16649

Focusing only on the scale rather than labs and body composition

Continued weight swings can stretch new scars or recreate laxity, reversing surgical gains

doi: 10.1007/s11154-022-09735-8