Decreased expression of GLUT1 reduces glucose uptake into the brain, leading to hypometabolism, which precedes cognitive impairment (Zlokovic, 2011
As an added precaution for patients with a reaction history within the previous five years, which makes them higher risk, a two-step DOC, starting with 10% of the target dose, is recommended
Acc Chem Res 54:26492659
[1] Finally, carnitine palmitoyltransferase II (CPT II), transfers the LCFA's from carnitine to CoA to make fatty-acyl CoA while transporting out the carnitine to translocase and eventually CPT I to restart the cycle and shuttle more LCFA's
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