The asterisk Like every drug, semaglutide comes with side effects and risks, including nausea, diarrhoea, constipation, dehydration, vomiting and headaches
Other factors to consider include the cost and the long-term use of the medication, which may be required to maintain weight loss and other health benefits.

Key benefits Why people compare it 1 22.5% mean body weight reduction at 15mg in SURMOUNT-1 (N=2,539, 72 weeks) 2 Dual GIP/GLP-1 receptor activation for combined metabolic effects beyond single-agonist therapy 3 63% of participants at highest dose achieved at least 20% weight loss vs 1.3% placebo 4 Superior A1C reduction of 2.07-2.59% with up to 97% of diabetic participants reaching target 5 Outperformed semaglutide 1mg head-to-head in SURPASS-2 for both weight and glycemic endpoints 6 Enhanced adipose tissue lipid handling and fat redistribution via GIPR signaling 7 Significant improvements in triglycerides, blood pressure, and waist circumference across all doses 8 Once-weekly dosing supported by 120-hour half-life and C20 fatty diacid albumin binding Deep research Tirzepatide is a 39-amino-acid synthetic peptide with a molecular weight of 4,813.45 Da

Affordable Options for Wegovy (Semaglutide) Until a generic version of Wegovy is available, you can find ways to make your prescription medications more affordable
On Medicaid, see Medicaid GLP-1 coverage by state first
Symptoms include recurrent episodes of hypoglycemia, typically fasting or post-exercise, but in some patients, the symptoms may occur during both fasting and postprandial periods, or rarely, only postprandial [6]