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The synergistic effect of combining hepsin with clinically low doses of NAC appeared to be more effective than the standard clinical care of high-dose NAC for APAP overdose

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This effect was similarly observed in a separate study on ovarian cancer [48]

Takeaways N-acetylcysteine (NAC) is a medication and dietary supplement with anti-inflammatory and antioxidant properties

Additionally, gene ontology analysis detected accumulation of transcripts related to the three steps of protein synthesis (initiation, elongation, termination) in Gclc fl/fl MZB compared to Gclc fl/fl FoB (Supplementary Fig