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On this basis, we can hypothesise that there could be a greater chance for cholecystoduodenal fistulae formation and subsequent gallstone ileus in Crohns disease patients

While this might sound worrying, it is usually part of the bodys process of adapting to the medication

This suggests a shared stress or inflammatory response across these conditions, possibly mediated through the hypothalamic-pituitary-adrenal (HPA) axis or other stress-related pathways