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Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia
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The expression of NRF1 is highest in skeletal muscle which is also the tissue that accounts for the largest percentage of glucose disposal in the body and, therefore, is the tissue that is most responsible for the hyperglycemia resulting from impaired insulin signaling
No refractory ascites or renal failure
The immune system produces autoantibodies against nuclear components (DNA, histones, ribosomes), and immune complex deposition causes inflammation in kidneys, skin, joints, brain, and blood vessels
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