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2) Dihexa was shown to improve cognitive impairments and recover memory by inhibiting inflammation and decreasing neuronal loss by affecting the PI3K/AKT signaling pathways

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Tabe, Y, Konopleva M, Tsao T, Lapillonne H, Jackson CE, Andreeff M

Interestingly, the excessive uptake of neuronal -synuclein by astrocytes can lead to accumulation of aggregates of this protein in astrocytes, and cause an upregulation of IL-1 , IL-1 and IL-6, followed by the release of TNF- and IL-6 [6]

and Fang, R