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Studies show that MDA levels significantly increase in IL-1- or erastin-induced OA mouse models, while 4-HNE and its protein adducts rise in the synovial fluid and chondrocytes of OA patients, underscoring the critical role of lipid peroxidation in OA pathology (Grigolo et al., 2003

doi: 10.1002/prca.200600745 235 Gharesi-FardBZolghadriJKamali-SarvestaniE

It's pretty good - I didn't notice any negative side-effects of the higher caffeine content

*Correspondence: Fook Choe Cheah, [email protected] This article was submitted to Neonatology, a section of the journal Frontiers in Pediatrics Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Patients with chronic knee pain reported relief lasting over 6 months in retrospective observations