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In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling
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Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK
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425 Peptide targeting of subcellular organelles offers a promising strategy to guide NADs to dysfunctional organelles, thus achieving optimal therapeutic effects
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