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As a result, even the most determined individuals struggle against biologically driven urges they cannot simply "will away." Another key issue is a sluggish metabolism

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doi: 10.3389/fcvm.2021.723886 Received 11 June 2021 Accepted 14 October 2021 Published 23 November 2021 Volume 8 - 2021 Edited by Dianjianyi Sun, Peking University, China Reviewed by Nhat Tu Le, Houston Methodist Research Institute, United States

A 2022 meta-analysis of 49 studies found that berberine can improve insulin resistance and have metabolic benefits, and has a small, but statistically significant, benefit for weight loss