Our body tries to fight back with natural antioxidants, but sometimes the shield isnt strong enough
doi: 10.1016/j.apsb.2024.05.025 40 UrsiniFMaiorinoMValenteMFerriLGregolinC
However, the most common presentation of CP-induced nephrotoxicity is acute kidney injury (AKI) (Miller et al., 2010), which is characterized by the rapid decline of renal excretory function leading to the accumulation of nitrogenous waste products, water, and electrolytes (Ostermann and Joannidis, 2016
Similar to albumin, AAT has exposed methionine (Met) residues and a free cysteine at the position 232, which can be attacked by oxidants
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