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A systematic review and meta-analysis including 35 RCTs demonstrated that BCAA supplementation improved muscle strength (standardized mean difference [SMD]: 0.35) and muscle mass (SMD: 0.25) in older adults, though improvements in physical function did not reach statistical significance (53)

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8 Currently, clinical trials are reporting the effectiveness of MASH treatments in terms of the percentage of participants whose liver fibrosis decreases by at least 1 stage on a scale ranging from 0 (normal) to 4 (cirrhosis)