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A controlled trial published in Human Physiology (Dolotov et al., 2006) showed that intranasal Semax at 200 mcg twice daily increased BDNF expression in the basal forebrain by approximately 70% over a seven-day period in patients with ischemic stroke
Feingold, B.F
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This reduces chronic stress-induced cortisol overproduction, a key driver of depressive symptoms (105, 123)
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