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In patients with AD, multiple clinical studies have demonstrated that systemic Vitamin D supplementation improves skin dryness and barrier dysfunction, with more pronounced efficacy observed in individuals with low baseline Vitamin D levels [254,255,256]

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Importantly, these findings were later corroborated by in vivo studies where both acute (single high-dose striatal injection) and sub-chronic (21 days of 30 mg/kg intranasal Mn) exposure reduced GLAST/GLT-1 expression and were associated with motor deficits, at doses approximating human Mn exposure (Johnson et al., 2018

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