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The molecule is engineered with a trans-3-hexenoic acid moiety covalently attached at the N-terminal tyrosine, a modification that confers significant resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4)

For maintenance therapy in individuals with dietary deficiency, doses of 50150 micrograms daily are often sufficient and better tolerated

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We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]