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It is evident from a growing number of studies that high-fat diets, drugs (antibiotics), and toxicants induce dysbiosis and improve the survivability of normally uncommon gut microbial species, leading to enhanced functional responses, pathogen infiltration, and further deterioration of gut health (Vascellari et al., 2021)

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After binding to the GHR, the intracellular Janus kinase-2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and ERK1/2 pathways are activated [8]

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Prescribers should document their clinical rationale, including the absence of contraindications, in the patient's medical record