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An important caveat for testing human mAbs in animal models is that human antibody Fc regions may not interact with animal FcRs in the same way as human FcRs 88

In laboratory studies, GHK-Cu is examined for its influence on extracellularmatrix-related pathways, including collagen- and glycosaminoglycan-associated readouts in controlled experimental systems

348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

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To address this question, we analyzed the capacity to restore the redox balance after reductive challenge in GSH-depleted cells producing periplasmic roGFP2 as described before

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