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Effects on the Brain and Circadian Rhythm GLP-1 receptors are present in parts of the brain that regulate: Sleep-wake cycles Hormone release Stress response Energy balance When semaglutide activates these pathways, the body may temporarily adjust its sleep rhythm

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Diabetes Obes Metab (2017) 19(2):21627

Am J Chin Med 31:885895 Chen X, Shen X, Guan Sh, Liu Y, Song N, Song W, Jin H (2025) Mechanisms of c-Fos regulation of mTOR signaling via ER/ in abnormal lipid metabolism of granulosa cells in PCOS