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doi: 10.1016/j.cgh.2015.02.019 230 SugimotoKIkeyaKBambaSAndohAYamasakiHMitsuyamaKet al

Some work also links DSIP with body temperature and pain perception

Because B12 is water-soluble, excess is excreted by the body

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Additionally, certain medications and genetic predispositions can increase susceptibility to developing hyperpigmentation, making it a multifaceted concern requiring targeted treatment approaches

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