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Extensive persistent inflammation even when SARS-CoV-2-infected cells are only sporadically present at late stages of COVID-19 (Schurink et al., 2020) could also justify low GSH levels in association with over-abundance of cellular ROS, cellular oxidative damage, increased inflammation and cell death pathways activation seen in inflammaging (Zuo et al., 2019

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Indeed, NTAPP induced more transcriptomic changes in genes associated with the Wnt signaling pathway than other pathways include Bmp-, Shh-, and Notch-pathway (Supplementary Figure 3c)

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