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As with any medication, there may be some side effects with anti-obesity drugs

The results demonstrate that GSHee (100 mol/kg, IV) has pronounced positive effects on breathing in freely-moving adult male SpragueDawley rats and that it markedly attenuates the deleterious effects elicited by subsequent injection of fentanyl (75 g/kg, IV) on minute ventilation, A-a gradient and ABG chemistry while extending the analgesic actions of the OR agonist

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Mol Cell Biochem 18:19 Alsubaie N, Al-Kuraishy HM, Al-Gareeb AI, Alharbi B, De Waard M, Sabatier JM, Saad HM, Batiha GE (2022) Statins use in alzheimer disease: bane or boon from frantic search and narrative review

"Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine"