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This phase 2 study showed promising results, but the study was small and only included 52 participants

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doi: 10.5604/17322693.1135042

Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

1- Ice the injection site Before injecting with vitamin B12, apply ice to your thigh, hip, or groin- wherever you plan on inserting the needle

Scientific References Pickart L, et al