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Maintenance and Long-Term Use: STEP-4 Trial: Participants who stopped semaglutide regained most weight Those who continued maintained loss and continued losing Suggests long-term treatment necessary for maintenance Most experts recommend: Treating obesity as chronic disease Long-term or indefinite medication use Transitioning to maintenance dose (not stopping) Combining with lifestyle changes for best results Understanding the complete comparison between semaglutide and tirzepatide helps determine which medication best fits your goals

Do we start with GLP-1

doi: 10.1007/s00125-008-1149-y 133 GromadaJFranklinIWollheimCB

Stock your kitchen with cold foods before week 5

Most users stay between 1mL and 3mL per 10mg of peptide

Cold water slows dissolution and can cause the powder to clump rather than dissolve evenly