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May 30 2021;22(11)doi:10.3390/ijms22115885

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In contrast, in the model group, astrocytes and microglia were significantly activated, exhibiting enlarged cell bodies, increased branching, and a significantly enhanced relative fluorescence intensity

62,99,100 Together, these reports provide strong evidence that after an APAP overdose, in vivo and in isolated hepatocytes in culture, ferrous iron can be released from lysosomes and then taken up into mitochondria via the MCFU, where it contributes to MPTP opening and cell death (Fig

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