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The trial was conducted in accordance with the standards of ethics outlined in the Declaration of Helsinki

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a RLM (1D): RLM incubation without fractionation, RLM (2D): RLM incubation with fractionation, 3A4 (1D): CYP3A4 Supersome incubation without fractionation, 3A4 (2D): CYP3A4 Supersome incubation with fractionation, DDA: confirmed by DDA, MRM: confirmed by MRM

The cytoplasm protein and nucleoprotein were obtained with an NE-PER Nuclear and Cytoplasmic Extraction Reagents (Thermo, USA)