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GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair

In another randomized controlled trial assessing the effect of hops extract on satiety in healthy-weight men, the treatment also led to a significant reduction in food intake, stimulated prelunch ghrelin, postprandial cholecystokinin, glucagon-like peptide 1, and peptide YY secretion compared to placebo (these neuropeptides promote fullness and reduce food intake) [2]

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The study concludes that CHAC1 is a novel UPR target gene negatively regulated by CHOP, revealing complex regulatory crosstalk in the UPR pathway and providing insights into the molecular mechanisms of oxidative stress and cell death (Nomura et al., 2020)

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