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4-6wks Typical cycle duration with proper medical monitoring and planned rest periods 1x/day Once-daily subcutaneous injection due to extended half-life Questions IGF-1 LR3 features a 13-amino acid N-terminal extension that extends its half-life from minutes to 20-30 hours and reduces binding to IGF binding proteins

Kurosawa, N., Shimizu, K

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doi: 10.1186/s13046-025-03432-5 26 ZhangJLiHTaoWZhouJ

Its indirect effect on growth hormone and IGF1 levels can also raise red flags on biomarker-based testing