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PMCID: PMC5312744

Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)

Laboratory studies in cell and animal models of accelerated aging have shown that replenishing NAD+ can restore mitochondrial function and stimulate beneficial cellular recycling processes like mitophagy

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