(4) Blood Pressure (3) In blood pressure studies, compared with l-arginine, pentadecapeptide BPC 157 (without effect on basal normal values) had both a mimicking effect (impaired l-NAME-blood pressure increase, when applied prophylactically and decreased already raised l-NAME values, given at the time of the maximal l-NAME-blood pressure increase (i.e., 10 min after l-NAME)) and preventive activity (l-arginine-induced moderate blood pressure decrease was prevented by BPC 157 pretreatment)
Dalle-Donne, I., et al.,S-glutathionylation in protein redox regulation
While it makes sense to hold these drugs during the acute phase of critical illness, implications of abrupt discontinuation, and the timing of restarting them are also areas that need further exploration
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