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Gastrointestinal adverse events including nausea, vomiting, and diarrhea are common with current GLP-1 agonists, leading some patients to discontinue treatment or fail to reach maximally effective doses

Patients with binge eating disorder who start a GLP-1 should initiate therapy at a low dose and titrate slowly

This includes providing comprehensive consultations to discuss treatment options, potential side effects, and expected outcomes

The olezarsen 50 mg dose did not result in a significant reduction in fasting TG levels from baseline compared to placebo at six months (LS mean difference, -22.4 percentage points

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GLP-1 receptor agonists seem to have the unique ability to reduce these effects without completely blocking dopamine release