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While agar-based nanoparticle systems are still emerging in BBB research, several universal design principles apply: These parameters are critical in adapting established ligand systems to agar-based nanoparticle platforms

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GLP1R itself has been shown to signal through the inhibitory Gi pathway after stimulation with GLP1R ligand in ovarian cells and in murine splenic monocytes after burn injury (42, 43)

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In contrast, the potential of protrusion-derived EVs for protein delivery remains largely unexplored