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Incentives that were at play for obesity drug development Suppose, in 2010, you believed that an effective, tolerable weight-loss drug would be worth $100bn

Dopamine responses are blunted: Substances like alcohol, nicotine, opioids, and stimulants normally send a surge of dopamine through reward pathways

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At that point, recovery is unreliable, and the batch often has to be discarded

Semaglutide is a human GLP-1 analogue that has 94% structural homology with native human GLP-1 and three important modifications [18] which extend its half-life in humans to approximately 1 week [18]